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In the fast-growing biopharmaceutical industry, the demand for high-quality veterinary vaccines is surging, driven by the need to protect livestock and pets from infectious diseases. Jiangsu Hanbon Technology Co., Ltd., a leader in purification equipment since 1998, is revolutionizing this field with innovative downstream purification solutions. With over 200 intellectual property rights and recognition as a national high-tech enterprise, Hanbon is a trusted partner for manufacturers worldwide.
In this blog post, we'll explore why veterinary vaccine purification is critical, the challenges in production, and how Hanbon's advanced technologies, like chromatography systems and ultrafiltration, deliver unmatched efficiency and quality.
Veterinary vaccines play a vital role in preventing disease outbreaks in animals, ensuring both animal welfare and food safety. China, a global leader in animal husbandry, raises 50% of the world’s pigs, 20% of its sheep, and 30% of its chickens using just 7% of the world's freshwater and 8% of its arable land. This high farming density—about 2.4 times the global average—increases the risk of epidemics, making vaccines indispensable.
Among animal health products, veterinary biologicals, especially vaccines, dominate the market, accounting for 80% of the sector. Unlike chemical drugs, vaccines align with the future of animal healthcare, offering significant growth potential.
Producing veterinary vaccines is complex, particularly in the downstream purification stage. Key challenges include:
Low Efficiency: Traditional methods like roller bottle cultures rely on manual processes, limiting scalability and output.
High Costs: Modern production often requires costly reagents, such as high-concentration serum, driving up expenses.
Impurities: Inadequate purification can leave residual proteins, reducing vaccine efficacy and triggering immune side effects.
These obstacles demand advanced downstream processing solutions to improve scalability, lower costs, and ensure vaccine purity.
Hanbon Technology provides a full range of purification equipment tailored for veterinary vaccine production. Our offerings include:
Automatic Axial Compression Chromatography Columns (ACC): A reliable solution for automatic column chromatography, delivering precise and consistent purification results.
Automated Tangential Flow Filtration (TFF) System: Streamline ultrafiltration and buffer exchange.
Buffer Preparation Systems: Automate buffer delivery for efficiency and sterility.
Homogenization Tanks and Cleaning Stations: Maintain hygiene and optimize workflows.
Beyond equipment, Hanbon's Turnkey services cover everything from sample pre-treatment to automation control, ensuring compliance with GMP and FDA standards. This all-in-one approach simplifies production and enhances quality.
Downstream purification is the process of isolating and refining vaccine antigens from a mix of proteins and impurities. The right purification technique depends on the protein’s properties, such as size, solubility, and binding behavior. Here are the key methods:
1. Ultrafiltration
This technique uses membranes to separate proteins by size. It’s widely applied in vaccines like foot-and-mouth disease (FMD) and pseudorabies, enhancing antigen concentration and purity.
2. Chromatography
Chromatography separates proteins based on specific traits:
Affinity Chromatography: Targets proteins using specific binding, ideal for high-purity results.
Hydrophobic Interaction Chromatography (HIC): Leverages hydrophobicity to remove impurities effectively.
3. Precipitation
By adjusting pH or ionic strength, proteins can be selectively precipitated, aiding initial separation.
These methods ensure vaccines meet rigorous safety and efficacy standards.
As the veterinary vaccine market expands, efficient and reliable downstream purification is more critical than ever. Hanbon Technology’s decades of experience and state-of-the-art solutions position them as a leader in this space. Whether you're producing vaccines for livestock or pets, Hanbon's purification systems ensure top-tier results.
