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At present, there are three main scales for customers to choose from: BioOligo 10 is mainly used for synthesis in the range of 10μmol-50μmol, Bio Oligo 100 is mainly used for synthesis in the range of 50μmol-9mmol, and Bio Oligo 150 is mainly used for synthesis in the range of 50μmol. This series of equipment adopts modular design and intelligent software, which can synthesise a certain amount of DNA/RNA by combining different sizes of synthesis columns, and the system can be used for clinical research, nucleic acid drug development and molecular diagnostic probe synthesis.
Stacked piping design, small dead volume, piping resistant to conventional organic solvents (acetonitrile, toluene), a certain concentration of dichloroacetic acid (3% ~ 10%) and other reagents;
PEEK material dual pump head with high flow accuracy and flow accuracy controlled at ± 1%; Flow repeatability: RSD ≤ 0.5%, pump head self-cleaning function;
Modular design that facilitates equipment maintenance, enables multi-user login and management, ensure information security and tracking;
Process parameters setting module customization, process method self-editing, good human-computer interaction experience;
Low reagent losses, high degree of automation, monitoring of synthesis pressure throughout, conductivity values, UV detection etc.
Cycle time: 4.5 ~25min (standard DNA), synthesis efficiency: > 99% for DNA, > 98% for RNA, can synthesize DNA / RNA of different sequence length;
Base monomer bottle quantities can be expanded to a maximum of 18, meeting the needs for the synthesis of modified monomers from a subset of customers;
Software design is compliant with the requirements of relevant laws and regulations such as 21 CFR Part 11.
| Model numbers | Bio-Oligo 10 | Bio-Oligo 100 | Bio-Oligo 150 |
| Size of synthesis | 1-50μmol | 50μmol-9mmol | 50μmol-12mmol |
| Solvent compatibility | Deprotection of actual, BTT, thio reagents, etc. | ||
| Piston pumps | PEEK material, pump head self-cleaning public, double pump head design, flow rate range 0~100ml/min | ||
| Syngeneic columns | 1 pcs | ||
| Single Entrance | Standard 8, expandable to 18 | ||
| Waste liquid outlet | 1 | ||
Maximum operating pressure | 15bar (218psi) | ||
| Inert gas pressure | Nitrogen/Argon 0.3~0.35 bar | ||
| UV Detector | Wavelength range 190~ 400nm, accuracy ±1nm (optional dual wavelength detector) | ||
| Conductivity Detector | 0～999mS/cm | ||
| Piping material | PTFE tube, PEEK tube | ||
| Single cycle time | <30min | ||
| Synthesis Efficiency | >99% for DNA >98% for RNA | ||
| Input Voltage | 220V±5% AC | ||
| power (output) | 900W | ||
| Weights | 55kg | ||
| Overall dimensions | 450*570*570mm | ||
| Operating Temperature | 10~40℃ | ||
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